75 Results for "

Millettia peguensis Ali

" in MedChemExpress (MCE) Product Catalog:
Products (75)

75 Results for "Millettia peguensis Ali" in MCE Product Catalog:

25
Piceatannol
Piceatannol
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25 Publications Verification
Cat. No.: HY-13518
CAS No.: 10083-24-6
Purity:  98.97%
Synonyms: Astringenin; trans-Piceatannol
Category:  

Microorganisms Rheum palmatum L. Stilbenes Polygonaceae Plants Disease Research Fields Cancer

Target:  

Syk Autophagy Apoptosis Endogenous Metabolite

Piceatannol is a well-known Syk inhibitor and reduces the expression of iNOS induced by TNF. Piceatannol is an effective agent for research of acute lung injury (ALI) . Piceatannol is a naturally occurring polyphenolic stilbene found in various fruits and vegetables and exhibits anticancer and anti-inflammatory properties . Piceatannol induces apoptosis in DLBCL cell lines . Piceatannol induces autophagy and apoptosis in MOLT-4 human leukemia cells .
6
Carmofur
Carmofur
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6 Cited Publications
Cat. No.: HY-B0182
CAS No.: 61422-45-5
Synonyms: HCFU
Target:  

Nucleoside Antimetabolite/Analog SARS-CoV Virus Protease FAAH Ceramidase Glutathione Peroxidase

Research Areas:  

Infection Inflammation/Immunology Cancer

Carmofur (HCFU) is a rat recombinant acid ceramidase inhibitor with an IC50 of 29 nM. Carmofur is also a protease inhibitor of SARS-CoV-2 main protease (Mpro), fatty acid amide hydrolase (FAAH) and N-acylethanolamine acid amidase (NAAA). Carmofur has anti-cancer, anti-inflammatory and anti-virus activities, and can be used for the study of COVID-19 and acute lung injury (ALI) .
5
HCH6-1
HCH6-1
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5 Cited Publications
Cat. No.: HY-101283
CAS No.: 1435265-06-7
Purity:  99.16%
Target:  

Formyl Peptide Receptor (FPR)

Research Areas:  

Inflammation/Immunology

HCH6-1 is a potent and competitive dipeptide antagonist of Formyl peptide receptor 1 (FPR1). HCH6-1 inhibits chemotaxis, superoxide anion generation, and elastase release in human neutrophils specifically activated by fMLF (an FPR1 agonist). HCH6-1 has protective effects against acute lung injury (ALI) in vivo and can be used for the research of FPR1-involved inflammatory lung diseases .
2
Aviptadil
Aviptadil
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2 Cited Publications
Cat. No.: HY-P0012
CAS No.: 40077-57-4
Synonyms: Vasoactive Intestinal Peptide (human, rat, mouse, rabbit, canine, porcine)
Target:  

SARS-CoV

Research Areas:  

Infection Inflammation/Immunology

Aviptadil is an analog vasoactive intestinal polypeptide (VIP) with potent vasodilatory effects. Aviptadil induces pulmonary vasodilation and inhibits vascular SMCs proliferation, platelet aggregation. Aviptadil can be used for the research of pulmonary fibrosis, pulmonary arterial hypertension (PAH) and SARS-CoV-2 caused respiratory failure, et al .
2
Plantamajoside
Plantamajoside
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2 Cited Publications
Cat. No.: HY-N0031
CAS No.: 104777-68-6
Category:  

Plantaginaceae Simple Phenylpropanols Phenols Polyphenols Plantago asiatica L. Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology

Target:  

NF-κB PI3K Akt Apoptosis Autophagy p38 MAPK Src

Plantamajoside is an orally active phenylpropanoid glycoside. Plantamajoside can be isolated from Plantago asiatica L.(Plantaginaceae). Plantamajoside inactivates NF-κB, PI3K/akt, induces Apoptosis, and improves Autophagy. Plantamajoside regulates MAPK, integrin-linked kinase/c-Src. Plantamajoside inhibits multiple cancers, improves lung and kidney damage. Plantamajoside has neuroprotective and anti-inflammatory effects .
2
Esculentoside A
Esculentoside A
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2 Cited Publications
Cat. No.: HY-N0632
CAS No.: 65497-07-6
Category:  

Triterpenes Terpenoids Phytolacca acinosa Roxb. Plants Disease Research Fields Inflammation/Immunology Phytolaccaceae

Target:  

COX NF-κB

Esculentoside A (EsA), a kind of triterpene saponin isolated from roots of Phytolacca esculenta . Esculentoside A (EsA) possesses anti-inflammatory activity in acute and chronic experimental models , has selective inhibitory activity towards cyclooxygenase-2 (COX-2) . Esculentoside A (EsA) suppresses inflammatory responses in LPS-induced acute lung injury (ALI) through inhibition of the nuclear factor kappa B (NF-ΚB) and mitogen activated protein kinase (MAPK) signaling pathways .
2
Hypaphorine
Hypaphorine
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2 Cited Publications
Cat. No.: HY-N2179
CAS No.: 487-58-1
Category:  

Alkaloids Neurological Disease Leguminosae Caragana korshinskii Metabolic Disease Abrus precatorius Linn. Plants Disease Research Fields Indole Alkaloids

Target:  

p38 MAPK JNK

Hypaphorine is an indole found in Caragana korshinskii. Hypaphorine has neurological and glucose-lowering effects. Hypaphorine prevents Lipopolysaccharides (LPS) (HY-D1056)-mediated acute lung injury (ALI) and proinflammatory response via inactivating the p38/JNK signaling pathway by upregulating DUSP1 .
2
Plantainoside D
Plantainoside D
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2 Cited Publications
Cat. No.: HY-N5063
CAS No.: 147331-98-4
Category:  

Cardiovascular Disease Simple Phenylpropanols Scrophulariaceae Phenols Polyphenols Phenylpropanoids Plants Picrorhiza scrophulariiflora Pennell Disease Research Fields

Target:  

Angiotensin-converting Enzyme (ACE) IKK Calcium Channel PKC Reactive Oxygen Species (ROS) NF-κB Apoptosis Sirtuin NOD-like Receptor (NLR)

Plantainoside D, a phenylethanoid glycosides, is a IKK-β inhibitor with diverse biological activities. Plantainoside D shows inhibitory activity of angiotensin-converting enzyme (ACE) with an IC50 of 2.17 mM. Plantainoside D significantly reduces the release of glutamate from nerve terminals in the cerebral cortex of rats by inhibiting the voltage-dependent calcium channel (VDCCs) and protein kinase C (PKC) signaling cascade. Plantainoside D significantly alleviates cell apoptosis by inhibiting the generation of ROS and the activation of NF-κB. Plantainoside D significantly improves acute lung injury (ALI) induced by sepsis by regulating the Sirt3/NLRP3 signaling pathway. Plantainoside D can be used for the study of neuroprotection, antioxidant, anti-inflammation, antihypertension .
2
Aviptadil acetate
Aviptadil acetate
0 Images
2 Cited Publications
Cat. No.: HY-P0012A
CAS No.: 1444827-29-5
Synonyms: Vasoactive Intestinal Peptide acetate salt (human, rat, mouse, rabbit, canine, porcine)
Target:  

SARS-CoV

Research Areas:  

Infection Inflammation/Immunology

Aviptadil acetate is an analog vasoactive intestinal polypeptide (VIP) with potent vasodilatory effects. Aviptadil acetate induces pulmonary vasodilation and inhibits vascular SMCs proliferation, platelet aggregation. Aviptadil acetate can be used for the research of pulmonary fibrosis, pulmonary arterial hypertension (PAH) and SARS-CoV-2 caused respiratory failure, et al .
1
MD2-TLR4-IN-1
MD2-TLR4-IN-1
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1 Cited Publications
Cat. No.: HY-128598
CAS No.: 2249801-12-3
Purity:  99.62%
Target:  

Toll-like Receptor (TLR) NF-κB

Research Areas:  

Inflammation/Immunology Cancer

MD2-TLR4-IN-1 is a myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex antagonist. MD2-TLR4-IN-1 inhibits Lipopolysaccharides (HY-D1056) (LPS)-induced expression of TNF-α and IL-6 in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively. MD2-TLR4-IN-1 can be used for the study of acute lung injury (ALI) .
1
Anti-inflammatory agent 35
Anti-inflammatory agent 35
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1 Cited Publications
Cat. No.: HY-148552
CAS No.: 2293951-00-3
Purity:  99.77%
Target:  

p38 MAPK ERK NF-κB Interleukin Related TNF Receptor

Research Areas:  

Inflammation/Immunology

Anti-inflammatory agent 35 (compound 5a27) is an orally active curcumin analogue with anti-inflammatory activity. Anti-inflammatory agent 35 blocks mitogen-activated protein kinase (MAPK) signaling and p65 nuclear translocation of NF-kB. Anti-inflammatory agent 35 also inhibits yellow neutrophil infiltration and pro-inflammatory cytokine production. Anti-inflammatory agent 35 significantly attenuates lipopolysaccharide (LPS)-induced acute lung injury (ALI) in vivo .
Oxypeucedanin
Oxypeucedanin
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Cat. No.: HY-N0747
CAS No.: 737-52-0
Category:  

Cardiovascular Disease Chrysanthemum × morifolium (Ramat.) Hemsl. Coumarins Phenylpropanoids Plants Umbelliferae Disease Research Fields

Target:  

Potassium Channel PI3K NF-κB Akt p38 MAPK ERK COX NO Synthase JNK Apoptosis

Oxypeucedanin is a furanocoumarin derivative found in Angelica dahurica. Oxypeucedanin is an orally active PI3K/AKT/NF-κB, MAPK, and ROS inhibitor. Oxypeucedanin induces cell cycle arrest and apoptosis. Oxypeucedanin inhibits hKv1.5 channel currents (IC50: 76 nM). Oxypeucedanin exhibits anticancer, anti-inflammatory, antioxidant and antiarrhythmic activities .
CLK1-IN-3
CLK1-IN-3
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Cat. No.: HY-149262
CAS No.: 2922550-28-3
Purity:  98.03%
Target:  

CDK DYRK Autophagy

Research Areas:  

Cancer

CLK1-IN-3 (compound 10ad) is a potent and selective Clk1 inhibitor, with an IC50 of 5 nM and over 300-fold selectivity for Dyrk1A. CLK1-IN-3 also shows a relatively potent inhibition against Clk2 and Clk4, with IC50 values of 42 and 108 nM, respectively. CLK1-IN-3 potently induces autophagy in vitro. CLK1-IN-3 can be used for acute liver injury (ALI) research .
Toxicarol isoflavone
Toxicarol isoflavone
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Cat. No.: HY-N1135
CAS No.: 3044-60-8
Category:  

other families Flavonoids Monophenols Phenols Plants Disease Research Fields Inflammation/Immunology Isoflavones

Target:  

Endogenous Metabolite

Toxicarol isoflavone is a natural isoflavone compound found in the leaves of Millettia brandisiana, and it belongs to flavonoid secondary metabolites .
(S,S)-Pisatin
(S,S)-Pisatin
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Cat. No.: HY-N3045
CAS No.: 20186-22-5
Category:  

Natural Products Leguminosae Other Diseases Pisum sativum Linn Plants Disease Research Fields

Target:  

Drug Isomer

(S,S)-Pisatin is a dimeric pterocarpan derivative. (S,S)-Pisatin can inhibit plant growth .
Daxdilimab
Daxdilimab
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Cat. No.: HY-P99226
CAS No.: 2245966-28-1
Synonyms: MEDI7734; VIB7734

Target:  

SARS-CoV Human leukocyte immunoglobulin (Ig)-like receptors (LILR)

Research Areas:  

Cancer

Daxdilimab is an anti-ILT7 monoclonal antibody, ILT7 is a cell surface molecule specific to the pDC type of dendritic cells. Daxdilimab can be used in acute lung injury (ALI) in patients with COVID-19 infection research .
Millepachine
Millepachine
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Cat. No.: HY-N7591
CAS No.: 1393922-01-4
Category:  

Flavonoids Chalcones Leguminosae Millettia pachycarpa Benth. Plants Disease Research Fields Cancer

Target:  

Apoptosis

Millepachine is a bioactive natural chalcone from Chinese herbal medicine Millettia pachycarpa Benth, exhibits strong antitumor effects against numerous human cancer cells both in vitro and in vivo .
MyD88-IN-3
MyD88-IN-3
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Cat. No.: HY-178136
Target:  

Toll-like Receptor (TLR) MyD88 p38 MAPK NF-κB JNK

Research Areas:  

Infection Inflammation/Immunology

MyD88-IN-3 is an orally active, selective MyD88 Inhibitor. MyD88-IN-3 specifically targets the TIR domain of MyD88 (KD = 28.5 μM), thereby preventing MyD88 self-polymerization and interaction with TLRs, which suppresses the activation of MAPK and NF-κB pathways. MyD88-IN-3 demonstrates significant anti-inflammatory efficacy and effectively mitigates Acute Lung Injury (ALI) symptoms in CLP (cecal ligation and puncture) and Lipopolysaccharides (HY-D1056) (LPS)-induced ALI models. MyD88-IN-3 can be used for the study of ALI .
MyD88-IN-2
MyD88-IN-2
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Cat. No.: HY-170446
CAS No.: 3067479-71-1
Target:  

MyD88

Research Areas:  

Inflammation/Immunology

MyD88-IN-2 (compound A5S) is a Myeloid differentiation primary response 88 (MyD88) inhibitor with the Kd of 15 μM. MyD88-IN-2 shows protective effects on LPS (HY-D1056)-induced and sepsis-induced ALI mouse models .
Dual Cathepsin L/JAK-IN-1
Dual Cathepsin L/JAK-IN-1
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Cat. No.: HY-170772
CAS No.: 2450279-41-9
Target:  

p38 MAPK STAT Interleukin Related Cathepsin JAK

Research Areas:  

Inflammation/Immunology

Dual Cathepsin L/JAK-IN-1 (Compound A8) is a dual inhibitor of Cathepsin L (CTSL) and JAK, with IC50 values of 0.68 μM, 337.1 nM, 5.251 nM, 27.29 nM, and 172.6 nM for CTSL, JAK1/2/3, and TYK2, respectively. Dual Cathepsin L/JAK-IN-1 effectively blocks the activation of the MAPK, NF-κB, and JAK/STAT signaling pathways, leading to significant anti-inflammatory therapeutic effects. Dual Cathepsin L/JAK-IN-1 can be used in research on acute lung injury (ALI) .
Assay Types